Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol
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چکیده
منابع مشابه
Gonadotropin-Releasing Response to Kisspeptin-10 and Its Modulation by Progesterone in Postpartum Cyclic Cows
The present study aimed to evaluate the effect of kisspeptin-10 (Kp10), a shorter variant of kisspeptin retaining full biological activity, on the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in cyclic adult cows, and the effect of plasma progesterone (P4)concentration on the response to Kp10 administration. The experiments were performed using five postpartum cows...
متن کاملKisspeptin and Gonadotropin-Releasing Hormone Neuronal Excitability: Molecular Mechanisms Driven by 17β-Estradiol.
Kisspeptin is a neuropeptide that signals via a Gαq-coupled receptor, GPR54, in gonadotropin-releasing hormone (GnRH) neurons and is essential for pubertal maturation and fertility. Kisspeptin depolarizes and excites GnRH neurons primarily through the activation of canonical transient receptor potential (TRPC) channels and the inhibition of K+ channels. The gonadal steroid 17β-estradiol (E2) up...
متن کاملDiurnal and estradiol-dependent changes in gonadotropin-releasing hormone neuron firing activity.
A robust gonadotropin-releasing hormone (GnRH) surge is a prerequisite signal for the luteinizing hormone (LH) surge that triggers ovulation. In rodents, the GnRH surge is initiated by elevated estradiol and a diurnal switch in estrogen action from negative to positive feedback. The ability of constant estradiol treatment to induce daily LH surges was tested in adult mice that were ovariectomiz...
متن کاملgonadotropin-releasing response to kisspeptin-10 and its modulation by progesterone in postpartum cyclic cows
the present study aimed to evaluate the effect of kisspeptin-10 (kp10), a shorter variant of kisspeptin retaining full biological activity, on the release of luteinizing hormone (lh) and follicle stimulating hormone (fsh) in cyclic adult cows, and the effect of plasma progesterone (p4)concentration on the response to kp10 administration. the experiments were performed using five postpartum cows...
متن کاملKisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54.
We have recently described a molecular gatekeeper of the hypothalamic-pituitary-gonadal axis with the observation that G protein-coupled receptor 54 (GPR54) is required in mice and men for the pubertal onset of pulsatile luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion to occur. In the present study, we investigate the possible central mode of action of GPR54 and kisspe...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2007
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2007-1365